Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Abstract
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated macrophages (TAMs), a hallmark of solid tumors, are typically correlated with poor prognosis. Here, we report a non-cell-autonomous mechanism, whereby human mutp53 cancer cells reprogram macrophages to a tumor supportive and...
Paper Details
Title
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Published Date
Feb 22, 2018
Journal
Volume
9
Issue
1
Pages
771 - 771
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