Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Volume: 9, Issue: 1, Pages: 771 - 771
Published: Feb 22, 2018
Abstract
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated macrophages (TAMs), a hallmark of solid tumors, are typically correlated with poor prognosis. Here, we report a non-cell-autonomous mechanism, whereby human mutp53 cancer cells reprogram macrophages to a tumor supportive and...
Paper Details
Title
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Published Date
Feb 22, 2018
Volume
9
Issue
1
Pages
771 - 771
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