Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
Abstract
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to...
Paper Details
Title
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
Published Date
Apr 9, 2018
Journal
Volume
33
Issue
4
Pages
649
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