Computational prediction of drug solubility in water-based systems : qualitative and quantitative approaches used in the current drug discovery and development setting

Volume: 540, Pages: 185 - 193
Published: Apr 5, 2018
Abstract
In this review we will discuss recent advances in computational prediction of solubility in water-based solvents. Our focus is set on recent advances in predictions of biorelevant solubility in media mimicking the human intestinal fluids and on new methods to predict the thermodynamic cycle rather than prediction of solubility in pure water through quantitative structure property relationships (QSPR). While the literature is rich in QSPR models...
Paper Details
Title
Computational prediction of drug solubility in water-based systems : qualitative and quantitative approaches used in the current drug discovery and development setting
Published Date
Apr 5, 2018
Volume
540
Pages
185 - 193
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