How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
Abstract
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic metabolism. However, their proliferation is marked by a shift towards increasing glycolytic metabolism even in the presence of O2 (Warburg effect). HIF1, a major hypoxia induced transcription factor, promotes a dissociation between glycolysis and the tricarboxylic acid cycle, a process limiting the efficient production of ATP and citrate which otherwise would...
Paper Details
Title
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
Published Date
May 1, 2018
Journal
Volume
38
Pages
1 - 11
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Notes
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