Hepatitis C virus core protein induces dysfunction of liver sinusoidal endothelial cell by down‐regulation of silent information regulator 1
Abstract
Hepatic fibrosis is a frequent feature of chronic hepatitis C virus (HCV) infection. Some evidence has suggested the potential role of silent information regulator 1 (SIRT1) in organ fibrosis. The aim of this study was to investigate the effect of HCV core protein on expression of SIRT1 of liver sinusoidal endothelial cell (LSEC) and function of LSEC. LSECs were co-cultured with HepG2 cells or HepG2 cells expressing HCV core protein and LSECs...
Paper Details
Title
Hepatitis C virus core protein induces dysfunction of liver sinusoidal endothelial cell by down‐regulation of silent information regulator 1
Published Date
Feb 2, 2018
Journal
Volume
90
Issue
5
Pages
926 - 935
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