Regulation of M1/M2 macrophage polarization by Sutherlandia frutescens via NFkB and MAPK signaling pathways

Sutherlandia frutescens is a medicinal plant, indigenous to South Africa, used to treat a number of conditions, including Type 2 Diabetes (T2D) and immune disorders. It is thought to have the capacity to regulate macrophage differentiation, thus impacting upon metabolic immune diseases and indicating a potential for ethnopharmaceutical use. In this paper we report the molecular action of S. frutescens with regard to in vitro macrophage...