Cooperation of DNA Helicases during dsDNA End Resection

Double strand DNA (dsDNA) break repair by homologous recombination in eukaryotes is a complex process that is not well understood at the molecular level. A main step of this process is the 5'-strand resection at the DNA break. In yeast, one resection mechanism involves the cooperation of two molecular motors: the RecQ helicase Sgs1 and the nuclease-helicase Dna2. These proteins unwind DNA in opposite directions while the produced single stranded...