Interleukin-35 stimulates hepatitis B virus transcription and replication by targeting transcription factor HNF4α

Volume: 99, Issue: 5, Pages: 645 - 654
Published: May 1, 2018
Abstract
Hepatitis B virus (HBV) infection is a major health problem worldwide. Interleukin-35 (IL-35) is a definite immunosuppressive cytokine belonging to the IL-12 family. Nevertheless, the role of IL-35 in HBV replication remains elusive. In this study, we found that the level of HBV DNA replicative intermediates detected by qPCR and Southern blotting analysis was significantly increased by rhIL-35 in a dose-dependent manner. Moreover, HBV 3.5 kb...
Paper Details
Title
Interleukin-35 stimulates hepatitis B virus transcription and replication by targeting transcription factor HNF4α
Published Date
May 1, 2018
Volume
99
Issue
5
Pages
645 - 654
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