Affinity maturation of an TpoR targeting antibody in full-length IgG form for enhanced agonist activity
Volume: 31, Issue: 7-8, Pages: 233 - 241
Published: Feb 21, 2018
Abstract
It has been observed that converting scFv formatted antibodies to full-length IgG often associates with loss of affinity. We aim to address this issue in this paper by establishing an integrated affinity maturation method applying yeast display technology platform. To demonstrate that, we employed a human thrombopoietin receptor targeting antibody named 3D9 which was identified previously from a combinational antibody library in scFv-Fc fusion...
Paper Details
Title
Affinity maturation of an TpoR targeting antibody in full-length IgG form for enhanced agonist activity
Published Date
Feb 21, 2018
Volume
31
Issue
7-8
Pages
233 - 241
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