Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Abstract
Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to study disease pathophysiology, we generated Mgme1 knockout mice and report that homozygous knockouts develop depletion and...
Paper Details
Title
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Published Date
Mar 23, 2018
Journal
Volume
9
Issue
1
Pages
1202 - 1202
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