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Value of 18F-FET PET in adult brainstem glioma

Published on Sep 1, 2018in Clinical Imaging1.136
· DOI :10.1016/j.clinimag.2018.01.015
Abdulrahman A. Albatly1
Estimated H-index: 1
(UZH: University of Zurich),
Adnan Taleb Alsamarah1
Estimated H-index: 1
(UZH: University of Zurich)
+ 6 AuthorsMartin Hüllner19
Estimated H-index: 19
(UZH: University of Zurich)
Abstract
Abstract Purpose To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). Materials and methods FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated. Results Progressive gliomas had higher SUVmax (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBRmax (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax   2.0 (665 ± 32 days versus 220 ± 39 days; p  Conclusion FET-PET uptake might be associated with disease progression in adult BSG.
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