Synthesis and biological evaluation of α -santonin derivatives as anti-hepatoma agents
Abstract
A series of α-santonin-derived compounds as potentially anti-hepatoma agents were designed and synthesized in an effort to find novel therapeutic agents. Among them, derivative 5h was more potent than the positive control 5-fluorouracil (5-Fu) on HepG-2, QGY-7703 and SMMC-7721 with IC50 values of 7.51, 3.06 and 4.08 μM, respectively. The structure-activity relationships (SARs) of these derivatives were discussed. In addition, flow cytometry and...
Paper Details
Title
Synthesis and biological evaluation of α -santonin derivatives as anti-hepatoma agents
Published Date
Apr 1, 2018
Volume
149
Pages
90 - 97
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