LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
Volume: 115, Issue: 18
Published: Mar 26, 2018
Abstract
Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new treatments targeting molecular pathways enriched in lethal prostate cancer. Lysine-specific demethylase 1 (LSD1) is a histone...
Paper Details
Title
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
Published Date
Mar 26, 2018
Volume
115
Issue
18
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