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TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells

Published on Sep 3, 2018in Connective Tissue Research2.167
路 DOI :10.1080/03008207.2018.1439483
Katie J. Sikes2
Estimated H-index: 2
(UIC: University of Illinois at Chicago),
Jun Li18
Estimated H-index: 18
(Rush University Medical Center)
+ 4 AuthorsVincent M. Wang26
Estimated H-index: 26
(UIC: University of Illinois at Chicago)
Abstract
ABSTRACTPurpose/Aim of the study: Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse injury or...
  • References (48)
  • Citations (2)
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References48
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#1David J. Niles (UW: University of Wisconsin-Madison)H-Index: 8
#2Jeremy W. Gordon (UW: University of Wisconsin-Madison)H-Index: 10
Last. Sean B. Fain (UW: University of Wisconsin-Madison)H-Index: 36
view all 7 authors...
2 CitationsSource
#1Stephanie G. Dakin (NOC: Nuffield Orthopaedic Centre)H-Index: 17
#2Christopher D. Buckley (Queen Elizabeth Hospital Birmingham)H-Index: 69
Last. Andrew Carr (NOC: Nuffield Orthopaedic Centre)H-Index: 93
view all 8 authors...
Background Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood.
25 CitationsSource
#1Shinichi Esaki (Nagoya City University)H-Index: 8
#2Fares Nigim (Harvard University)H-Index: 6
Last. Hiroaki Wakimoto (Harvard University)H-Index: 57
view all 12 authors...
Despite the current standard of multimodal management, glioblastoma (GBM) inevitably recurs and effective therapy is not available for recurrent disease. A subset of tumor cells with stem-like properties, termed GBM stem-like cells (GSCs), are considered to play a role in tumor relapse. Although oncolytic herpes simplex virus (oHSV) is a promising therapeutic for GBM, its efficacy against recurrent GBM is incompletely characterized. Transforming growth factor beta (TGF-尾) plays vital roles in ma...
6 CitationsSource
#1Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
#2Tommy Frisgaard 脴hlenschl忙ger (UCPH: University of Copenhagen)H-Index: 3
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 7 authors...
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy, but evidence for this treatment is lacking, and little is known regarding effects of NSAIDs on human tendinopathic tendon. This study investigated effects of NSAID treatment (ibuprofen) on human tendinopathic tendon, with changes in gene expression as the primary outcome, and tendon pain, function and blood flow as secondary outcomes. Twenty-six adults (16 male, 10 female) diagnosed with chronic Achilles tend...
5 CitationsSource
#1Ting-An Wang (Guangxi Medical University)H-Index: 2
#2Shu-Lin Xian (Guangxi Medical University)H-Index: 3
Last. Yun-Fei Lu (Guangxi Medical University)H-Index: 4
view all 5 authors...
2 CitationsSource
#1Shao-Hua Yang (University of North Texas Health Science Center)H-Index: 43
#2Wenjun Li (University of North Texas Health Science Center)H-Index: 11
Last. Ran Liu (University of North Texas Health Science Center)H-Index: 5
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Abstract Brain has exceptional high requirement for energy metabolism with glucose as the exclusive energy source. Decrease of brain energy metabolism and glucose uptake has been found in patients of Alzheimer's, Parkinson's and other neurodegenerative diseases, providing a clear link between neurodegenerative disorders and energy metabolism. On the other hand, cancers, including glioblastoma, have increased glucose uptake and rely on aerobic glycolysis for energy metabolism. The switch of high ...
21 CitationsSource
#1Katrina E. Allison (Ontario Veterinary College)H-Index: 1
#2Brenda L. Coomber (Ontario Veterinary College)H-Index: 23
Last. Byram W. Bridle (Ontario Veterinary College)H-Index: 16
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Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to glycolysis and upregulating glutaminolysis to divert carbon sources into biosynthetic pathways that promote proliferation and survival. Therefore, metabolic inhibitors represent promising anti-cancer drugs. However, T cells must rapidly divide and survive in harsh microenvironments to mediate anti-cancer effects. Metabolic profiles of cancer cells and activated T lymphocytes are similar, raising the risk...
16 CitationsSource
#1Hao Ding (Nanjing Medical University)H-Index: 1
#2Lei Jiang (Nanjing Medical University)H-Index: 112
Last. Junwei Yang (Nanjing Medical University)H-Index: 34
view all 9 authors...
Chronic kidney diseases generally lead to renal fibrosis. Despite great progress having been made in identifying molecular mediators of fibrosis, the mechanism that governs renal fibrosis remains unclear, and so far no effective therapeutic antifibrosis strategy is available. Here we demonstrated that a switch of metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect) in renal fibroblasts was the primary feature of fibroblast activation during renal fibrosis and that sup...
16 CitationsSource
#1Chu-Yik Tang (QMUL: Queen Mary University of London)H-Index: 1
#2Claudio Mauro (QMUL: Queen Mary University of London)H-Index: 22
Cellular metabolism has been known for its role in bioenergetics. In recent years, much light has been shed on the reprogrammable cellular metabolism underlying many vital cellular processes like cell activation, proliferation, and differentiation. Metabolic reprogramming in immune and endothelial cells (ECs) is being studied extensively. These cell compartments are implicated in inflammation and pathogenesis of many diseases but their similarities in metabolic reprogramming have not been analyz...
13 CitationsSource
#1Moeed Akbar (Glas.: University of Glasgow)H-Index: 8
#2Derek S. Gilchrist (Glas.: University of Glasgow)H-Index: 12
Last. Neal L. Millar (Glas.: University of Glasgow)H-Index: 16
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Objectives To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. Methods Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing 鈥榚arly pathology鈥) biopsies were collected from patients undergoing arthroscopic shoulder surgery. Control samples of subscapularis t...
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#1Sophia K. Theodossiou (UIdaho: University of Idaho)H-Index: 1
#2Nathan R. Schiele (UIdaho: University of Idaho)H-Index: 12
Tendons link muscle to bone and transfer forces necessary for normal movement. Tendon injuries can be debilitating and their intrinsic healing potential is limited. These challenges have motivated the development of model systems to study the factors that regulate tendon formation and tendon injury. Recent advances in understanding of embryonic and postnatal tendon formation have inspired approaches that aimed to mimic key aspects of tendon development. Model systems have also been developed to ...
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