Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring

Published on Aug 1, 2018in The FASEB Journal5.39
· DOI :10.1096/fj.201701263RR
Maria Manti1
Estimated H-index: 1
(KI: Karolinska Institutet),
Romina Fornes5
Estimated H-index: 5
(KI: Karolinska Institutet)
+ 6 AuthorsElisabet Stener-Victorin43
Estimated H-index: 43
(KI: Karolinska Institutet)
Maternal polycystic ovary syndrome (PCOS), a condition associated with hyperandrogenism, is suggested to increase anxiety-like behavior in the offspring. Because PCOS is closely linked to obesity, we investigated the impact of an adverse hormonal or metabolic maternal environment and offspring obesity on anxiety in the offspring. The obese PCOS phenotype was induced by chronic high-fat–high-sucrose (HFHS) consumption together with prenatal dihydrotestosterone exposure in mouse dams. Anxiety-like behavior was assessed in adult offspring with the elevated-plus maze and open-field tests. The influence of maternal androgens and maternal and offspring diet on genes implicated in anxiety were analyzed in the amygdala and hypothalamus with real-time PCR (n = 47). Independent of diet, female offspring exposed to maternal androgens were more anxious and displayed up-regulation of adrenoceptor α 1B in the amygdala and up-regulation of hypothalamic corticotropin-releasing hormone (Crh). By contrast, male offspring e...
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#1Cooney Lg (HUP: Hospital of the University of Pennsylvania)H-Index: 1
#2Lee I (HUP: Hospital of the University of Pennsylvania)H-Index: 1
Last.Dokras A (HUP: Hospital of the University of Pennsylvania)H-Index: 1
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#1Yingchen Wu (SYSU: Sun Yat-sen University)H-Index: 1
#2Guangzheng Zhong (SYSU: Sun Yat-sen University)H-Index: 1
Last.Meiqing Xie (SYSU: Sun Yat-sen University)H-Index: 2
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#1Carolyn E. Cesta (KI: Karolinska Institutet)H-Index: 3
#2Mattias Månsson (KI: Karolinska Institutet)H-Index: 4
Last.Mikael Landén (KI: Karolinska Institutet)H-Index: 47
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#1I.B. Ressler (UC: University of Cincinnati)H-Index: 3
#2Bernadette E. Grayson (UMMC: University of Mississippi Medical Center)H-Index: 23
Last.Randy J. Seeley (UM: University of Michigan)H-Index: 87
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#1Peter CelecH-Index: 27
#2Daniela Ostatníková (Comenius University in Bratislava)H-Index: 16
Last.Július Hodosy (Comenius University in Bratislava)H-Index: 17
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Cited By4
#1Maria Manti (KI: Karolinska Institutet)H-Index: 1
#2Romina Fornes (KI: Karolinska Institutet)H-Index: 5
Last.Elisabet Stener-Victorin (KI: Karolinska Institutet)H-Index: 43
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#1Lisa Lindheim (University of Graz)H-Index: 2
#2Maria Manti (KI: Karolinska Institutet)H-Index: 1
Last.Barbara Obermayer-Pietsch (University of Graz)H-Index: 43
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