Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

Published on Jun 1, 2018in Carbohydrate Polymers6.04
· DOI :10.1016/j.carbpol.2018.02.058
Junping Zheng4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences),
Xubing Yuan3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
+ 6 AuthorsHongtao Liu19
Estimated H-index: 19
(CAS: Chinese Academy of Sciences)
Abstract The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose ( P   0.01) and reversed the insulin resistance ( P   0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators ( P   0.05), down-regulating the lipogenesis ( P   0.01) and inhibiting the adipocyte differentiation ( P   0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin ( P   0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia ( P   0.01) and suppressing Helicobacter ( P   0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.
  • References (45)
  • Citations (19)
#1José A. Caparrós-Martín (Curtin University)H-Index: 14
#2Ricky R. Lareu (Curtin University)H-Index: 3
Last.Fergal O'Gara (UCC: University College Cork)H-Index: 54
view all 11 authors...
#1Pengfei Xu (BNU: Beijing Normal University)H-Index: 7
#2Jialin Wang (BNU: Beijing Normal University)H-Index: 3
Last.Yonggong Zhai (BNU: Beijing Normal University)H-Index: 8
view all 8 authors...
#1Xiaofei Sun (WSU: Washington State University)H-Index: 7
#2Qiyuan Yang (WSU: Washington State University)H-Index: 14
Last.Mei-Jun Zhu (WSU: Washington State University)H-Index: 26
view all 5 authors...
Cited By19
#1Junping Zheng (Hubei University of Chinese Medicine)
#2Jing Zhang (Hubei University of Chinese Medicine)
Last.Hongtao Liu (Hubei University of Chinese Medicine)
view all 9 authors...
#1Lei Zhong (NAU: Nanjing Agricultural University)H-Index: 4
#2Ning Ma (NAU: Nanjing Agricultural University)
Last.Qiuhui Hu (NAU: Nanjing Agricultural University)H-Index: 34
view all 6 authors...
#1Cuiting Zhi (Guangdong Pharmaceutical University)
#2Jingqing Huang (Guangdong Pharmaceutical University)
Last.Zhengquan Su (Guangdong Pharmaceutical University)H-Index: 9
view all 7 authors...
#1Armelle Ménard (University of Bordeaux)H-Index: 28
#2Annemieke Smet (University of Antwerp)H-Index: 20
#1Yuting Liu (Hefei University of Technology)
#2Shuai Zong (Hefei University of Technology)H-Index: 6
Last.Jinglei Li (Hefei University of Technology)H-Index: 11
view all 3 authors...
#1Zhiwen Zhang (Jiangnan University)H-Index: 1
#2Hongyu Xu (Jiangnan University)H-Index: 11
Last.Zhenghong Xu (Jiangnan University)H-Index: 24
view all 8 authors...
#1Yuqing Chen (Fujian Agriculture and Forestry University)H-Index: 3
#2Dan Liu (Fujian Agriculture and Forestry University)H-Index: 3
Last.Chao Zhao (Fujian Agriculture and Forestry University)H-Index: 3
view all 10 authors...
View next paperGut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults