Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

A Comparison of Fresenius Com.Tec Cell and Spectra Optia Cell Separators for Autologous and Allogeneic Stem Cell Collections: Single Center Experience

Published on Oct 1, 2018in Indian Journal of Hematology and Blood Transfusion 0.87
· DOI :10.1007/s12288-018-0922-4
Serife Medeni Solmaz1
Estimated H-index: 1
,
Selda Kahraman1
Estimated H-index: 1
(Medical Park)
+ 8 AuthorsFatih Demirkan11
Estimated H-index: 11
(Dokuz Eylül University)
Cite
Abstract
Peripheral blood is the prefered source for hematopoietic stem cells for hematopoietic stem cell transplantation. The efficiency of peripheral blood stem cell (PBSC) collection can vary among devices. In this study we aimed to compare feasibility and effectivity of apheresis procedures of the different systems. Two apheresis systems [Com.Tec (Fresenius Healthcare) and Spectra Optia (Caridian BCT)] were used in our center for the collection of PBSCs for autologous and allogeneic transplantation. We retrospectively analysed 190 apheresis procedures performed in healthy donors and patients between June 2012 and November 2014 in Department of Hematology, Dokuz Eylul University. PBSCS were collected by Fresenius cell separator (64 procedure) or Spectra Optia cell separator (126 procedure). Mobilization treatments were G-CSF (26.8%), cyclophosphamide plus G-CSF (48.4%), prelixafor plus G-CSF (14.7%), ESHAP (10%) and others. Patient and donor characteristics (age, weight, volume processed, disease, mobilization regimes) were similar in Fresenius and Spectra Optia apheresis groups. Altough both collected PBSCs efficiently, the amount of CD34+ cell in product collected by Spectra Optia device was significantly higher (p < 0.05) and product volume was lower than Fresenius Com.Tec significantly (p < 0.05). “CD34+ collection efficiency” with Spectra Optia was significantly higher than Fresenius Com.Tec (CE2: 87%, 70%, p = 0.033) regarding all procedures. High collection efficiency and low product volume may be a significant characteristic of Spectra Optia device (mean 187 mL, product CD34+ cell: 1576 µL).
  • References (19)
  • Citations (0)
Cite
References19
Newest
Published on Aug 1, 2015in Transfusion and Apheresis Science 1.41
Melda Cömert Özkan3
Estimated H-index: 3
(Ege University),
Fahri Sahin9
Estimated H-index: 9
(Ege University),
Guray Saydam18
Estimated H-index: 18
(Ege University)
Most frequently used graft of hematopoietic stem cells (HSCs) for allogeneic transplantation is peripheral blood stem cells (PBSCs) that are collected after mobilization with frequently granulocyte colony-stimulating factor (G-CSF). Administration of the optimal dose of G-CSF while preserving the donor health is one of the most important points for sufficient PBSC mobilization and harvest. We hereby tried to summarize characteristic features, potential side effects and main topics in peripheral ...
9 Citations Source Cite
Published on Feb 1, 2015in Journal of Clinical Apheresis 3.09
Marleen M. Neyrinck2
Estimated H-index: 2
(Delta Air Lines),
H. Vrielink16
Estimated H-index: 16
It’s important to work smoothly with your apheresis equipment when you are an apheresis nurse. Attention should be paid to your donor/patient and the product you’re collecting. It gives additional value to your work when you are able to calculate the efficiency of your procedures. You must be capable to obtain an optimal product without putting your donor/patient at risk. Not only the total blood volume (TBV) of the donor/patient plays an important role, but also specific blood values influence ...
13 Citations Source Cite
Published on Dec 1, 2013in Transfusion and Apheresis Science 1.41
Sabine Flommersfeld2
Estimated H-index: 2
,
Tamam Bakchoul20
Estimated H-index: 20
(University of Giessen)
+ 3 AuthorsUlrich J. Sachs28
Estimated H-index: 28
(University of Giessen)
Three different apheresis systems were used in our center for the collection of peripheral blood progenitor cells (PBPCs): COM.TEC (Fresenius Healthcare), COBE Spectra, and Spectra Optia (both from Caridian BCT). We compared 131 autologous and 56 allogeneic apheresis procedures to elucidate feasibility and effectiveness of the different systems. Collection efficiacy varied significantly with lowest results obtained with COBE Spectra. COM.TEC and Spectra Optia produced lower WBC contamination tha...
21 Citations Source Cite
Published on Dec 1, 2012in Transfusion and Apheresis Science 1.41
Fei-yi Wu1
Estimated H-index: 1
(SGH: Singapore General Hospital),
Kee Khiang Heng1
Estimated H-index: 1
(SGH: Singapore General Hospital)
+ 9 AuthorsLip Kun Tan5
Estimated H-index: 5
Peripheral blood stem cells (PBSC) have become the most common source of hematopoietic cells for allogeneic or autologous blood and marrow transplantation (BMT). We performed an evaluation of PBSC collections using three different apheresis systems in two major transplantation centers in Singapore. Patients undergoing autologous BMT and donors col- lecting for allogeneic BMT were harvested using the COBE Spectra, Haemonetics MCS+, or Baxter Amicus. There were 99 Spectra collections (61 were auto...
11 Citations Source Cite
Published on Jul 1, 2012in Biology of Blood and Marrow Transplantation 3.60
Carlos Bachier12
Estimated H-index: 12
,
Josh Potter1
Estimated H-index: 1
+ 6 AuthorsCharles F. LeMaistre21
Estimated H-index: 21
Seizures as a complication of the infusion of autologous peripheral blood stem cells (PBSC) are rare. Seizures during infusion of autologous PBSC in 3 of our patients prompted us to review our cell therapy and cytapheresis protocols and procedures. We retrospectively analyzed 159 adult patients collected between January 2006 and July 2009. Patients were collected on either the COBE Spectra (Caridian BCT, Lakewood, CO) cell separator (n = 85) or Fresenius AS (Fresenius Kabi AG, Bad Homburg, Germa...
9 Citations Source Cite
Published on May 1, 2012in Transfusion 3.11
Susanne Brauninger6
Estimated H-index: 6
,
Heike Bialleck9
Estimated H-index: 9
+ 3 AuthorsHalvard Bonig28
Estimated H-index: 28
BACKGROUND: Granulocyte–colony-stimulating factor–mobilized peripheral blood stem cells, collected by white blood cell apheresis, are used for more than 80% of allogeneic and most autologous hematopoietic stem cell transplantations. Optimal donor and recipient outcomes require maximized stem cell collection efficiency and minimized non–target cell contamination. Therefore, improved apheresis technology is desirable. The safety and feasibility of apheresis collections with the novel, electronics-...
56 Citations Source Cite
Published on Oct 1, 2011in Vox Sanguinis 2.36
Susanne Brauninger6
Estimated H-index: 6
(German Red Cross),
Heike Bialleck4
Estimated H-index: 4
(German Red Cross)
+ 2 AuthorsHalvard Bonig28
Estimated H-index: 28
(German Red Cross)
Background and Objectives G-CSF mobilized peripheral blood stem/progenitor cells are frequently used for allogeneic transplantation. Available manual apheresis systems generate stem cell products of consistently high quality. Short-comings include need for continuous interface monitoring/adjustment, interface instability in donors with inconsistent blood flow, high collection variability, high platelet loss, and failure to electronically document apheresis parameters. Material and Methods A fund...
40 Citations Source Cite
Published on Feb 1, 2011in Transfusion 3.11
Suk-Ran Kim5
Estimated H-index: 5
(SMC: Samsung Medical Center),
Hae-Kyoung Choung1
Estimated H-index: 1
(SMC: Samsung Medical Center)
+ 2 AuthorsEun-Suk Kang13
Estimated H-index: 13
(SMC: Samsung Medical Center)
BACKGROUND: This study was conducted to evaluate the performance of the COM.TEC cell separator (Fresenius HemoCare GmbH) for collecting CD34+ cells in pediatric patients who were intended to have autologous peripheral blood progenitor cell transplantation, with respect to collection variables, prediction power of CD34+ cell yield, and influence on donors. STUDY DESIGN AND METHODS: A total of 26 pediatric solid tumor patients who received mobilization chemotherapy and granulocyte–colony-stimulati...
10 Citations Source Cite
Published on Apr 1, 2007in Transfusion and Apheresis Science 1.41
Fevzi Altuntas14
Estimated H-index: 14
,
Ismail Kocyigit14
Estimated H-index: 14
+ 7 AuthorsAli Unal19
Estimated H-index: 19
Abstract Peripheral blood progenitor cells (PBPC) are commonly used as a stem cell source for autologous transplantation. This study was undertaken to evaluate blood cell separators with respect to separation results and content of the harvest. Forty autologous PBPC collections in patients with hematological malignancies were performed with either the Amicus or the COM.TEC cell separators. The median product volume was lower with the Amicus compared to the COM.TEC (125 mL vs. 300 mL; p 6 vs. 4.1...
10 Citations Source Cite
Published on Dec 1, 2006in Journal of Clinical Apheresis 3.09
Claudia Del Fante15
Estimated H-index: 15
,
Cesare Perotti26
Estimated H-index: 26
+ 5 AuthorsLaura Salvaneschi21
Estimated H-index: 21
At the moment, PBSC collections can be performed using semi-automated or automated cell separator devices. The automated methods offer the advantages of a decreased working load for dedicated personnel and high standardization of the collection procedure. Herein we report our single institutional experience in 80 PBSC collections employing the new automated COM.TEC Fresenius autoMNC program that provides the ability to predict the total number of CD34+ cells collected, based on the pre-leukapher...
9 Citations Source Cite
Cited By0
Newest