Role of dysfunctional adipocytes in cholesterol-induced nonobese metabolic syndrome

Many studies have reported the causes of obese metabolic syndrome (MS); however, the causes of nonobese MS (NMS) remain unknown. In this study, we demonstrated that inflamed dysfunctional adipose tissue plays a crucial role in cholesterol-induced NMS. Control (C), high cholesterol (HC) and HC with 10% fructose in drinking water (HCF) diets were fed to Sprague–Dawley rats for 12 weeks. After 12 weeks, the body weights of the C- and HC-fed rats...