An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Volume: 14, Issue: 4, Pages: 396 - 404
Published: Mar 19, 2018
Abstract
Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating processes in these ion channels are still unknown. To gain insights into the lipid-sensing principle, we generated a DAG photoswitch, OptoDArG, that enabled efficient control of TRPC3 by light. A structure-guided mutagenesis screen of the TRPC3 pore domain unveiled a single...
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Paper Details
Title
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.
Published Date
Mar 19, 2018
Volume
14
Issue
4
Pages
396 - 404
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