Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention

Changes in the bone marrow microenvironment, which accompany aging and obesity, including increased marrow adiposity, can compromise hematopoiesis. Here, we review deleterious shifts in molecular, cellular, and tissue activity and consider the potential of exercise to slow degenerative changes associated with aging and obesity. While bone marrow hematopoietic stem cells (HSC) are increased in frequency and myeloid-biased with age, the effect of...