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Endothelial nitric oxide synthase polymorphisms affect the changes in blood pressure and nitric oxide bioavailability induced by propofol

Published on May 1, 2018in Nitric Oxide3.37
· DOI :10.1016/j.niox.2018.02.007
Gustavo H. Oliveira-Paula9
Estimated H-index: 9
(USP: University of São Paulo),
Riccardo Lacchini16
Estimated H-index: 16
(USP: University of São Paulo)
+ 5 AuthorsJose E. Tanus-Santos34
Estimated H-index: 34
(USP: University of São Paulo)
Abstract
Abstract Propofol anesthesia is usually accompanied by hypotension, which is at least in part related to enhanced endothelial nitric oxide synthase (NOS3)-derived NO bioavailability. We examined here whether NOS3 polymorphisms (rs2070744, 4b/4a VNTR, rs3918226 and rs1799983) and haplotypes affect the changes in blood pressure and NO bioavailability induced by propofol. Venous blood samples were collected from 168 patients at baseline and after 10 min of anesthesia with propofol 2 mg/kg administered intravenously by bolus injection. Genotypes were determined by polymerase chain reaction and haplotype frequencies were estimated. Nitrite concentrations were measured by using an ozone-based chemiluminescence assay, while NOx (nitrites + nitrates) levels were determined by using the Griess reaction. We found that CT + TT genotypes for the rs3918226 polymorphism, the ba + aa genotypes for the 4b/4a VNTR and the CTbT haplotype were associated with lower decreases in blood pressure and lower increases in nitrite levels after propofol anesthesia. On the other hand, the TCbT and CCbT haplotypes were associated with more intense decreases in blood pressure and higher increases in nitrite levels in response to propofol. Our results suggest that NOS3 polymorphisms and haplotypes influence the hypotensive responses to propofol, possibly by affecting NO bioavailability.
  • References (51)
  • Citations (2)
References51
Newest
#1Qi Zhong (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Xiangdong Chen (HUST: Huazhong University of Science and Technology)H-Index: 1
Last.Shanglong Yao (HUST: Huazhong University of Science and Technology)H-Index: 16
view all 5 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 25
view all 3 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (State University of Campinas)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 25
view all 7 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 3 authors...
#1Pritam Sinharoy (KSU: Kent State University)H-Index: 5
#2Hongyu Zhang (Southwest General Health Center)H-Index: 3
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
view all 6 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 6 authors...
Cited By2
Newest
#1Marcelo R. Luizon (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
#2Daniela A. Pereira (UFMG: Universidade Federal de Minas Gerais)H-Index: 1
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 3 authors...
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