Hexim1, an RNA-controlled protein hub
Abstract
Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). In addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor...
Paper Details
Title
Hexim1, an RNA-controlled protein hub
Published Date
Feb 23, 2018
Journal
Volume
9
Issue
4
Pages
262 - 271
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Notes
History