Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.

Volume: 4, Issue: 1, Pages: 12 - 12
Published: Mar 13, 2018
Abstract
5-hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes through the 5-HT receptor family. Here we report the crystal structure of 5-HT1B subtype receptor (5-HT1BR) bound to the psychotropic serotonin receptor inverse agonist methiothepin (MT). Crystallization was facilitated by replacing ICL3 with a novel optimized variant of BRIL (OB1) that enhances the formation of intermolecular polar interactions, making...
Paper Details
Title
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.
Published Date
Mar 13, 2018
Volume
4
Issue
1
Pages
12 - 12
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