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Comparison of reproducibility of single voxel spectroscopy and whole-brain magnetic resonance spectroscopy imaging at 3T.

Published on Apr 1, 2018in NMR in Biomedicine3.414
· DOI :10.1002/nbm.3898
Yue Zhang12
Estimated H-index: 12
(UAB: University of Alabama at Birmingham),
Edward Taub77
Estimated H-index: 77
(UAB: University of Alabama at Birmingham)
+ 6 AuthorsDavid C. Knight24
Estimated H-index: 24
(UAB: University of Alabama at Birmingham)
Abstract
  • References (63)
  • Citations (5)
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References63
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#1Maiken K. Brix (University of Bergen)H-Index: 5
#2Lars Ersland (University of Bergen)H-Index: 26
Last. Alexander R. Craven (University of Bergen)H-Index: 7
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Purpose The reproducibility of the MEGA-PRESS (MEshcher-GArwood Point RESolved Spectroscopy) MR spectroscopy sequence for the measurement of gamma- aminobutyric acid (GABA) is addressed, focusing on optimizing the number of repetitions at two voxel locations in the human brain and associated possibilities in analysis tools. Materials and Methods Two 20-min MEGA-PRESS acquisitions were run (echo time = 68 ms, repetition time = 1800 ms, repetitions = 328): one from a 21 mL volume in the anterior c...
12 CitationsSource
4 CitationsSource
#1Muhammad G. Saleh (Johns Hopkins University)H-Index: 8
#2Jamie Near (McGill University)H-Index: 22
Last. Ernesta M. Meintjes (UCT: University of Cape Town)H-Index: 12
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Objective Measuring the pure form of GABA has become increasingly important because of its association with behaviour and certain pathologies. The aim of this study was to assess the reproducibility of GABA measurements using a shim and motion navigated MEGA-SPECIAL sequence with LCModel, jMRUI and GANNET software.
10 CitationsSource
#1Jessica McKay (UMN: University of Minnesota)H-Index: 2
#2Ivan Tkáč (UMN: University of Minnesota)H-Index: 39
11 CitationsSource
#1Mohammed Goryawala (UM: University of Miami)H-Index: 12
#2Sulaiman Sheriff (UM: University of Miami)H-Index: 12
Last. Andrew A. Maudsley (UM: University of Miami)H-Index: 51
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Glutamate (Glu) and glutamine (Gln) play an important role in neuronal regulation and are of value as MRS-observable diagnostic biomarkers. In this study the relative concentrations of these metabolites have been measured in multiple regions in the normal brain using a short-TE whole-brain MRSI measurement at 3 T combined with a modified data analysis approach that used spatial averaging to obtain high-SNR spectra from atlas-registered anatomic regions or interest. By spectral fitting of high-SN...
14 CitationsSource
#1Mohammad Sabati (UM: University of Miami)H-Index: 10
#2Sulaiman Sheriff (UM: University of Miami)H-Index: 12
Last. Andrew A. Maudsley (UM: University of Miami)H-Index: 51
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Purpose To assess volumetric proton MR spectroscopic imaging (MRSI) of the human brain on multivendor MRI instruments. Methods Echo-planar spectroscopic imaging was developed on instruments from three manufacturers, with matched specifications and acquisition protocols that accounted for differences in sampling performance, radiofrequency (RF) power, and data formats. Intersite reproducibility was evaluated for signal-normalized maps of N-acetylaspartate (NAA), creatine (Cre), and choline using ...
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#1Najib AllaïliH-Index: 4
#2Romain ValabregueH-Index: 29
Last. Malgorzata Marjanska (UMN: University of Minnesota)H-Index: 26
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The hippocampus is crucial for long-term episodic memory and learning. It undergoes structural change in aging and is sensitive to neurodegenerative and psychiatric diseases. MRS studies have seldom been performed in the hippocampus due to technical challenges. The reproducibility of MRS in the hippocampus has not been evaluated at 3 T. The purpose of the present study was to quantify the concentration of metabolites in a small voxel placed in the hippocampus and evaluate the reproducibility of ...
14 CitationsSource
#1Najib AllaïliH-Index: 4
#2Romain ValabregueH-Index: 29
Last. Malgorzata MarjanskaH-Index: 26
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#1Angèle Lecocq (AMU: Aix-Marseille University)H-Index: 3
#2Yann Le Fur (AMU: Aix-Marseille University)H-Index: 26
Last. Jean-Philippe Ranjeva (AMU: Aix-Marseille University)H-Index: 41
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BACKGROUND: To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers. METHODS: Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15° plane were obtained at 3 Tesla in a group ...
15 CitationsSource
#1Xiao-Qi Ding (MHH: Hannover Medical School)H-Index: 14
#2Heinrich Lanfermann (MHH: Hannover Medical School)H-Index: 40
Objective Accompanying the advance of neuroscientific research and modern therapeutic methods, efforts have been made to develop more practical and effective advanced magnetic resonance (MR) spectroscopic techniques.
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#2Korbinian Eckstein (Medical University of Vienna)H-Index: 3
Last. Wolfgang Bogner (Medical University of Vienna)H-Index: 25
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Purpose: In this study, we demonstrate the first combination of 3D FID proton MRSI and spatial encoding via concentric-ring trajectories (CRTs) at 3T. FID-MRSI has many benefits including high detection sensitivity, in particular for J-coupled metabolites (e.g., glutamate/glutamine). This makes it highly attractive, not only for clinical, but also for, potentially, functional MRSI. However, this requires excellent reliability and temporal stability. We have, therefore, augmented this 3D-FID-MRSI...
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#1Juan R. Bustillo (UNM: University of New Mexico)H-Index: 44
#2Joel Upston (UNM: University of New Mexico)
Last. Rhoshel K. Lenroot (UNM: University of New Mexico)H-Index: 39
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Proton magnetic resonance spectroscopy (1H-MRS) studies have examined glutamatergic abnormalities in schizophrenia, mostly in single voxels. Though the critical brain nodes remain unknown, schizophrenia involves networks with broad abnormalities. Hence, glutamine plus glutamate (Glx) and other metabolites were examined with whole-brain 1H-MRS, in early schizophrenia. Three dimensional 1H-MRS was acquired in young schizophrenia subjects (N = 36, 19 antipsychotic-naive and 17 antipsychotic-treated...
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#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 12
#2Edward Taub (UAB: University of Alabama at Birmingham)H-Index: 77
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Assessing brain temperature can provide important information about disease processes (e.g., stroke, trauma) and therapeutic effects (e.g., cerebral hypothermia treatment). Whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) is increasingly used to quantify brain metabolites across the entire brain. However, its feasibility and reliability for estimating brain temperature needs further validation. Therefore, the present study evaluates the reproducibility of WB-MRSI for temperature ma...
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BACKGROUND AND PURPOSE: Mutations in isocitrate dehydrogenase (IDH) have a direct effect on gliomagenesis. The purpose of this study is to quantify differences in brain metabolites due to IDH mutations. METHODS: Magnetic Resonance Spectroscopic Imaging (MRSI) was performed in 35 patients with gliomas of different grade and varied IDH mutation status. Volumes of interest (VOIs) for active tumor (tVOI), peritumoral area (pVOI), and contralateral normal-appearing white matter (cVOI) were created. M...
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Cardiovascular risk factors such as dyslipidemia and hypertension increase the risk for white matter pathology and cognitive decline. We hypothesize that white matter levels of N-acetylaspartate (NAA), a chemical involved in the metabolic pathway for myelin lipid synthesis, could serve as a biomarker that tracks the influence of cardiovascular risk factors on white matter prior to emergence of clinical changes. To test this, we measured levels of NAA across white matter and gray matter in the br...
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Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for its core symptoms. This has led some families and researchers to trial alternative remedies – including the non-intoxicating Cannabis sativa-derived compound cannabidivarin (CBDV). However, how CBDV affects the human brain is unknown. Previous (pre)clinical evidence suggests that CBDV may modulate brain excitatory-inhibitory systems, which are implicated...
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Abstract The glutamate hypothesis of schizophrenia posits aberrant glutamatergic activity in patients with schizophrenia. Levels of glutamate and glutamine can be detected and quantified in vivo by proton magnetic resonance spectroscopy. A related technique, proton magnetic resonance spectroscopic imaging (1H-MRSI), is particularly useful as it simultaneously collects multiple spectra, across multiple voxels, from a single acquisition. The primary aim of this study was to review and discuss the ...
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Purpose A mouse model of Alzheimer’s disease demonstrates reduced beta-amyloid levels in the whole brain, associated with a gain of hippocampal memory, after drinking taurine-enriched water; this suggests that a taurine supplement could be a promising treatment for cognitive deficit. The objective of this study is to establish a methodology for quantifying taurine in the whole brain, taking advantage of the rapid development of non-invasive imaging techniques such as magnetic resonance imaging a...
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