Two Partial T Cell Depletion Strategies for Unrelated Donor Peripheral Stem Cell Transplantation are Associated with Excellent Outcomes for Pediatric Patients with Bone Marrow Failure (BMF)

Background: HSCT for patients with BMF lacking a matched related donor (MRD) is limited by increased risk of graft failure and GvHD. Use of matched (MUD) or mismatched unrelated donor (MMUD) peripheral stem cell transplantation (PSCT) with partial T cell depletion (pTCD) for patients with BMF has potential advantages of enabling high donor stem cell doses for efficient engraftment while reducing GvHD. We present outcomes of 12 patients with BMF...