Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
Abstract
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator of pro-resilient...
Paper Details
Title
Estrogen receptor α drives pro-resilient transcription in mouse models of depression.
Published Date
Mar 16, 2018
Journal
Volume
9
Issue
1
Pages
1116 - 1116
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Notes
History