Andrographolide relieved pathological pain generated by spared nerve injury model in mice

Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia.The objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model.Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and...