Insulin Detemir Use Is Associated With Higher Occurrence of Hypoglycemia in Hospitalized Patients With Hypoalbuminemia

The insulin analogs detemir and glargine are the two basal insulins commonly used in hospitalized patients (1). Their slow-release reservoir is different—serum albumin for detemir and subcutaneous microcrystals for glargine (2,3). There is a common belief that detemir should be avoided in hypoalbuminemic patients because they have less predictable levels of free insulin, raising a concern for higher risk of hypoglycemia (4,5). Nevertheless, the...