Association of HERG and SCN5A Transcripts Regulates Ion Channel Expression and Function in Stem Cell Derived Cardiomyocytes

The balance of ion currents that generate the cardiac electrical impulse is crucial for proper heart function. Perturbation in the expression of either the rapid delayed rectifying potassium channel gene (KCNH2) or the sodium channel gene (SCN5A) can result in dramatic cardiac arrhythmias and sudden death, but how cardiac cells coordinate expression of these channels is unknown. We recently demonstrated that alternate transcripts from the KCNH2...