Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs

Metformin is used in pregnancy in women with gestational diabetes mellitus, polycystic ovary syndrome (PCOS), and obesity. Metformin passes the placenta.To explore the effects of metformin use in PCOS pregnancies on offspring growth to 4 years of age.Follow-up study of two randomized, double-blind, placebo-controlled trials.Secondary care centers. Eleven public hospitals in Norway.One hundred eighty-two children of mothers with PCOS who...