Mechanisms of ketamine action as an antidepressant
Abstract
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative anesthetic ketamine induces rapid and sustained antidepressant actions. Although this finding has been met with enthusiasm, ketamine's widespread use is limited by its abuse potential and dissociative properties. Recent preclinical research has focused on unraveling the molecular mechanisms underlying the antidepressant actions of ketamine in an effort to...
Paper Details
Title
Mechanisms of ketamine action as an antidepressant
Published Date
Mar 13, 2018
Journal
Volume
23
Issue
4
Pages
801 - 811
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History