New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling
Abstract
RAS is the most frequently mutated gene across human cancers, but developing inhibitors of mutant RAS has proven to be challenging. Given the difficulties of targeting RAS directly, drugs that impact the other components of pathways where mutant RAS operates may potentially be effective. However, the system-level features, including different localizations of RAS isoforms, competition between downstream effectors, and interlocking feedback and...
Paper Details
Title
New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling
Published Date
Feb 1, 2019
Journal
Volume
54
Pages
162 - 173
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Notes
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