How should we compare different genomic estimates of the strength of inbreeding depression?

Yengo et al. (1) evaluate the ability of genomic measures of inbreeding to quantify inbreeding depression. The authors conclude that a measure of inbreeding based on “runs of homozygosity” ( F ROH) had low power and upwardly biased estimates of the amount of inbreeding depression compared with F HOM (a measure of homozygosity relative to Hardy–Weinberg proportions) and F UNI (correlation between uniting gametes; similar to F HOM but with strong...