Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Abstract
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly...
Paper Details
Title
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Published Date
Mar 1, 2018
Journal
Volume
97
Issue
6
Pages
1268 - 1283.e6
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