HSF4 transcriptional regulates HMOX-1 expression in HLECs
Abstract
The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial...
Paper Details
Title
HSF4 transcriptional regulates HMOX-1 expression in HLECs
Published Date
May 1, 2018
Journal
Volume
655
Pages
30 - 34
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