MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Abstract
Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role in atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits and macrophage burden in atherosclerotic plaques. We also demonstrate that MT4-MMP deficiency results in higher numbers of patrolling monocytes crawling and adhered to inflamed...
Paper Details
Title
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Published Date
Mar 2, 2018
Journal
Volume
9
Issue
1
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