Deaminase-mediated multiplex genome editing in Escherichia coli
Abstract
In eukaryotes, the CRISPR–Cas9 system has now been widely used as a revolutionary genome engineering tool1, 2. However, in prokaryotes, the use of nuclease-mediated genome editing tools has been limited to negative selection for the already modified cells because of its lethality3, 4. Here, we report on deaminase-mediated targeted nucleotide editing (Target-AID) 5 adopted in Escherichia coli. Cytidine deaminase PmCDA1 fused to the...
Paper Details
Title
Deaminase-mediated multiplex genome editing in Escherichia coli
Published Date
Feb 5, 2018
Journal
Volume
3
Issue
4
Pages
423 - 429
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