Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism.

Published on Feb 8, 2018in PLOS ONE2.78
· DOI :10.1371/journal.pone.0191182
Wang Y8
Estimated H-index: 8
('SMMU': Second Military Medical University),
Zhenzhen Liu1
Estimated H-index: 1
('SMMU': Second Military Medical University)
+ 3 AuthorsZhao-Shen Li38
Estimated H-index: 38
('SMMU': Second Military Medical University)
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism. Further investigation demonstrated that the increased mitochondrial biogenesis and metabolism is mediated through the activation of Akt and AMPK signaling pathways and inhibition of TGF-β signaling pathway. Collectively, our findings indicate a beneficial effect of dietary MCT in exercise performance through the increase of mitochondrial biogenesis and metabolism.
  • References (34)
  • Citations (3)
Published on Mar 1, 2017in Journal of Cardiac Failure3.86
Ismael Saifudeen1
Estimated H-index: 1
Lakshmi Subhadra1
Estimated H-index: 1
+ 1 AuthorsR. Renuka Nair1
Estimated H-index: 1
Abstract Background Left ventricular hypertrophy (LVH) is characterized by a decrease in oxidation of long-chain fatty acids, possibly mediated by reduced expression of the cell-surface protein cluster of differentiation 36 (CD36). Spontaneously hypertensive rats (SHRs) were therefore supplemented with medium-chain triglycerides (MCT), a substrate that bypasses CD36, based on the assumption that the metabolic modulation will ameliorate ventricular remodeling. Methods The diet of 2-month-old and ...
Published on May 1, 2016in Journal of Nutrition4.42
Sakiko Abe2
Estimated H-index: 2
Osamu Ezaki46
Estimated H-index: 46
(Showa Women's University),
Motohisa Suzuki2
Estimated H-index: 2
Sarcopenia, the loss of skeletal muscle mass, strength, and function, is common in elderly individuals but difficult to treat.A combination of nutrients was investigated to treat sarcopenia in very frail elderly adults.We enrolled 38 elderly nursing home residents (11 men and 27 women with a mean ± SD age of 86.6 ± 4.8 y) in a 3-mo randomized, controlled, single-blind, parallel group trial. The participants were randomly allocated to 3 groups. The first group received a daily l-leucine (1.2 g) a...
Published on Nov 1, 2015in Life Sciences3.45
Jiexiu Zhao2
Estimated H-index: 2
Lili Lai2
Estimated H-index: 2
+ 4 AuthorsSantiago Lorenzo10
Estimated H-index: 10
Abstract Aims This study aimed to test the hypothesis that different neurotransmitters and hormones are presented at exercise fatigue in hot temperatures with differing relative humidities (RH). Main methods Eight trained male athletes performed a graded maximum oxygen consumption (VO 2 max) test in five different environmental conditions, namely, 21 °C/20% RH (Normal), 33 °C/20% RH (Hot 20%), 33 °C/40% RH (Hot 40%), 33 °C/60% RH (Hot 60%), and 33 °C/80% RH (Hot 80%). Blood samples were taken pr...
Published on Nov 1, 2015in Mitochondrion3.45
Anna Picca3
Estimated H-index: 3
(University of Bari),
Angela Maria Serena Lezza17
Estimated H-index: 17
(University of Bari)
Abstract Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA and interactions between TFAM and mtDNA participate to regulation of mitochondrial biogenesis. Such interactions are modulated through different mechanisms: regulation of TFAM expression and turnover, modulation of TFAM binding activity to mtDNA through post-translational modifications and differential affinity o...
Published on Mar 1, 2015in Pharmacology & Therapeutics9.40
Cindy Neuzillet5
Estimated H-index: 5
(French Institute of Health and Medical Research),
Annemilaï Tijeras-Raballand16
Estimated H-index: 16
+ 4 AuthorsArmand de Gramont10
Estimated H-index: 10
Abstract The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. TGFβ signaling deregulation is frequent in tumors and has crucial roles in tumor initiation, development and metastasis. TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matte...
Published on Feb 1, 2015in Journal of the Academy of Nutrition and Dietetics4.14
Karen Mumme1
Estimated H-index: 1
Welma Stonehouse16
Estimated H-index: 16
Abstract Background Medium-chain triglycerides (MCTs) may result in negative energy balance and weight loss through increased energy expenditure and lipid oxidation. However, results from human intervention studies investigating the weight reducing potential of MCTs, have been mixed. Objective To conduct a systematic review and meta-analysis of randomized controlled trials comparing the effects of MCTs, specifically C8:0 and C10:0, to long-chain triglycerides (LCTs) on weight loss and body compo...
Published on Oct 1, 2014in European Journal of Clinical Nutrition3.11
Marie-Pierre St-Onge37
Estimated H-index: 37
Mayrsohn B1
Estimated H-index: 1
+ 3 AuthorsBlandine Laferrère34
Estimated H-index: 34
Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men
Published on Dec 1, 2013in Journal of Lipid Research4.74
Magdalene K. Montgomery11
Estimated H-index: 11
(UNSW: University of New South Wales),
Brenna Osborne12
Estimated H-index: 12
(UNSW: University of New South Wales)
+ 4 AuthorsNigel Turner44
Estimated H-index: 44
(UNSW: University of New South Wales)
Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation and insulin resistance, diets rich in medium-chain fatty acids (MCFAs) have been associated with increased oxidative metabolism and reduced adiposity, with few deleterious effects on insulin action. The molecular mechanisms underlying these differences between dietary fat subtypes are poorly understood. To investigate this further, we treate...
Published on Sep 1, 2013in European Journal of Nutrition4.45
Miriam E. Clegg12
Estimated H-index: 12
(Oxford Brookes University),
Mana Golsorkhi2
Estimated H-index: 2
(Oxford Brookes University),
C. Jeya K. Henry21
Estimated H-index: 21
(Oxford Brookes University)
Background and purpose Capsaicin, the active ingredient of chilli, and medium-chain triglycerides (MCT) have been shown to increase diet-induced thermogenesis (DIT), improve satiety and decrease energy intake. Combinations of thermogenic ingredients have previously been investigated such as mustard and chilli, or capsaicin and green tea with positive effects. The aim of this study was to investigate the combined effects of chilli and MCT feeding on DIT and satiety in healthy volunteers.
Published on May 1, 2013in Nature Reviews Cancer51.85
Lalage M. Wakefield1
Estimated H-index: 1
Caroline S. Hill45
Estimated H-index: 45
The transforming growth factor-β (TGFβ) ligands have important functions in cancer. However, it is now becoming apparent that many of the other TGFβ superfamily members (bone morphogenetic proteins (BMPs), activins, NODAL, and growth and differentiation factors (GDFs)) have crucial roles in tumorigenesis and metastasis; these are the focus of this Review.
Cited By3
Published on Jan 10, 2019in Molecules3.06
Thu Huong Pham2
Estimated H-index: 2
Natalia P. Vidal1
Estimated H-index: 1
+ 4 AuthorsRaymond Thomas1
Estimated H-index: 1
Fatty acid esters of hydroxy fatty acids (FAHFA), diglycerides (DG) and monoacetyldiglycerides (MAcDG) are gaining interest as functional lipids in pharmaceuticals and functional food formulations for managing and treating metabolic or inflammatory diseases. Herein, we investigated whether the antler and/or meat of two Cervids (moose and caribou) are novel sources of FAHFA, DG and MAcDG. We observed FAHFA present in moose and caribou composed mainly of polyunsaturated families, and that the este...
Published on Jan 1, 2019in Prostaglandins Leukotrienes and Essential Fatty Acids2.86
Janaina Guimarães (UERJ: Rio de Janeiro State University), Thereza Cristina Lonzetti Bargut9
Estimated H-index: 9
(Federal Fluminense University)
+ 1 AuthorsMarcia Barbosa Aguila29
Estimated H-index: 29
(UERJ: Rio de Janeiro State University)
Abstract We aimed to investigate the effects of medium-chain triglyceride oil on the high fructose diet-provoked hepatic abnormalities in mice. We used C57bl/6 mice of 3-months-old divided into four groups for 12 weeks: control (C), control with MCT (C-MCT), fructose (F), and fructose with MCT (F-MCT). We investigated food and water intake, body mass, blood pressure, glucose tolerance, plasma and liver biochemistry, hepatic protein and gene expression. There were no changes in body mass, food in...
Published on Oct 1, 2018in Trends in Food Science and Technology8.52
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Soorya Parathodi Illam4
Estimated H-index: 4
(University of Calicut),
Achuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Abstract Background Edible oils, preferably plant origin are rich sources of fatty acids and other lipophilic antioxidants to the body. Among these, oils derived from the coconut kernel ( Cocos nucifera ) are widely used in India and the Asia Pacific, which includes copra oil (CO), virgin coconut oil (VCO) and refined, bleached and deodorized (RBD) oil. Based on the mode of preparation, their composition and biological effects vary. Scope and approach This review compares the physicochemical and...
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