Match!

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions:

Published on Feb 1, 2018in Pulmonary circulation2.08
· DOI :10.1177/2045894018764171
Ting Wang18
Estimated H-index: 18
(UA: University of Arizona),
Mary E. Brown19
Estimated H-index: 19
(UIC: University of Illinois at Chicago)
+ 5 AuthorsJoe G. N. Garcia87
Estimated H-index: 87
(UA: University of Arizona)
Cite
Abstract
Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y464 and Y471 phosphorylation resulting in translocation of nmMLCK to the periphery where spatially-directed increases in myosin light chain (MLC) phosphorylation and tension result in lamellipodia protrusion, increased cell-cell adhesion, and enhanced vascular barrier integrity. MYLK, the gene encoding nmMLCK, is a known candidate gene in lung inflammatory diseases, with coding genetic variants (Pro21His, Ser147Pro, Val261Ala) that confer risk for inflammatory lung injury and influence disease severity. The functional mechanisms by which these MYLK coding single nucleotide polymorphisms (SNPs) affect biologic processes to increase disease risk and severity remain elusive. In the current study, we utilized quantifiable cell immunofluorescence assays to determine the influence of M...
  • References (31)
  • Citations (4)
Cite
References31
Newest
#1P. Viswanathan (UIC: University of Illinois at Chicago)H-Index: 1
#2Y. Ephstein (UIC: University of Illinois at Chicago)H-Index: 1
Last.Sm Dudek (UIC: University of Illinois at Chicago)H-Index: 1
view all 5 authors...
#1Kui Shen (UIC: University of Illinois at Chicago)H-Index: 1
#2Benjamin E. Ramirez (UIC: University of Illinois at Chicago)H-Index: 7
Last.Ting Wang (UA: University of Arizona)H-Index: 18
view all 10 authors...
#1Patrick Belvitch (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Djanybek Adyshev (UIUC: University of Illinois at Urbana–Champaign)H-Index: 16
Last.Steven M. Dudek (UIUC: University of Illinois at Urbana–Champaign)H-Index: 35
view all 9 authors...
#1Ting Wang (UA: University of Arizona)H-Index: 18
#2Liliana Moreno-Vinasco (UIC: University of Illinois at Chicago)H-Index: 25
Last.Joe G. N. Garcia (UA: University of Arizona)H-Index: 87
view all 10 authors...
#1Fernando Teran Arce (UCSD: University of California, San Diego)H-Index: 26
#2Brian Meckes (UCSD: University of California, San Diego)H-Index: 7
Last.Ratnesh Lal (UCSD: University of California, San Diego)H-Index: 39
view all 6 authors...
Cited By4
Newest
#1Stephanie Wallace (University of Texas Health Science Center at Houston)H-Index: 3
#2Ellen S. Regalado (University of Texas Health Science Center at Houston)H-Index: 24
Last.Catherine Boileau (Paris Diderot University)H-Index: 55
view all 10 authors...
#1Patrick Belvitch (UIC: University of Illinois at Chicago)H-Index: 5
#2Yu Maw Htwe (UIC: University of Illinois at Chicago)H-Index: 1
Last.Steven M. Dudek (UIC: University of Illinois at Chicago)H-Index: 35
view all 4 authors...
View next paperNon-Muscle Myosin Light Chain Kinase (nmMLCK) Phosphorylation by Abl Tyrosine Kinase Is Essential in Lung Endothelial Cell Cytoskeletal Rearrangement and Barrier Regulation.