Structures reveal opening of the store-operated calcium channel Orai
Abstract
The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER). Loss- and gain-of-function mutants of Orai cause disease. Our previous work revealed the structure of Orai with a closed pore. Here, using a gain-of-function mutation that constitutively activates the channel, we...
Paper Details
Title
Structures reveal opening of the store-operated calcium channel Orai
Published Date
Aug 30, 2018
Journal
Volume
7
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Notes
History