Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy

To determine whether fibrin clot properties are associated with clinical outcomes following acute coronary syndrome (ACS). Plasma samples were collected at hospital discharge from 4354 ACS patients randomized to clopidogrel or ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. A validated turbidimetric assay was employed to study plasma clot lysis time and maximum turbidity (a measure of clot density). One-year rates of...