KRAS induces lung tumorigenesis through microRNAs modulation
Abstract
Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that have been established as main players in tumorigenesis. By overexpressing wild type or mutant KRAS (KRASG12D) and using inducible human and mouse cell lines, we analyzed KRAS-regulated microRNAs in non-small-cell lung cancer (NSCLC). We show that miR-30c and miR-21 are...
Paper Details
Title
KRAS induces lung tumorigenesis through microRNAs modulation
Published Date
Feb 13, 2018
Journal
Volume
9
Issue
2
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