Improvement of Reliability of Diffusion Tensor Metrics in Thigh Skeletal Muscles

Objective Quantitative diffusion tensor imaging (DTI) of skeletal muscles is challenging due to the bias in DTI metrics, such as fractional anisotropy (FA) and mean diffusivity (MD), related to insufficient signal-to-noise ratio (SNR). This study compares the bias of DTI metrics in skeletal muscles via pixel-based and region-of-interest (ROI)-based analysis. Methods DTI of the thigh muscles was conducted on a 3.0-T system in N = 11 volunteers...