hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Abstract
Chronic myeloid leukemia (CML) stem/progenitor cells (SPCs) express a transcriptional program characteristic of proliferation, yet can achieve and maintain quiescence. Understanding the mechanisms by which leukemic SPCs maintain quiescence will help to clarify how they persist during long-term targeted treatment. We have identified a novel BCR-ABL1 protein kinase-dependent pathway mediated by the upregulation of hsa-mir183, the downregulation of...
Paper Details
Title
hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Published Date
Apr 5, 2018
Journal
Volume
131
Issue
14
Pages
1532 - 1544
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