Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease
Published on May 1, 2018in European Journal of Preventive Cardiology5.64
· DOI :10.1177/2047487318760618
BackgroundNeutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis.Design and methodsWe investigated whether the circulating neutrophil extracellular traps markers, double-stranded DNA and myeloperoxidase-DNA were associated with clinical outcome and hypercoagulability in patients with stable coronary artery disease. Patients with angiographically verified stable coronary artery disease (n = 1001) were included. Follow-up was 2 years, recording 106 clinical endpoints (unstable angina, non-haemorrhagic stroke, myocardial infarction or death). Serum collected at baseline was used to determine double-stranded DNA and myeloperoxidase-DNA levels.ResultsThe neutrophil extracellular traps markers were weakly intercorrelated (r = 0.103, P = 0.001). Patients with the highest quartile of double-stranded DNA had weakly but significantly elevated hypercoagulability markers (prothrombin fragment 1+2, D-dimer, free and total tissue factor pathway inhibitor (P <...