Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis
Abstract
The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses inflicted by host immunity. Improving our understanding of these defense pathways can reveal vulnerable points in Mtb pathogenesis. In this study, we combined genetic, structural, computational, biochemical, and biophysical approaches to identify a novel enzyme class...
Paper Details
Title
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis
Published Date
Feb 21, 2018
Journal
Volume
4
Issue
5
Pages
771 - 787
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History