Diverse genetic error modes constrain large-scale bio-based production
Abstract
A transition toward sustainable bio-based chemical production is important for green growth. However, productivity and yield frequently decrease as large-scale microbial fermentation progresses, commonly ascribed to phenotypic variation. Yet, given the high metabolic burden and toxicities, evolutionary processes may also constrain bio-based production. We experimentally simulate large-scale fermentation with mevalonic acid-producing Escherichia...
Paper Details
Title
Diverse genetic error modes constrain large-scale bio-based production
Published Date
Feb 20, 2018
Journal
Volume
9
Issue
1
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