GWAS on family history of Alzheimer’s disease

Riccardo E. Marioni; Sarah E. Harris; Qian Zhang; Allan F. McRae; Saskia P. Hagenaars; WD Hill; Gail Davies; Craig W. Ritchie; Catharine R. Gale; John M. Starr; Naomi R. Wray; Peter M. Visscher

doi:https://doi.org/10.1038/s41398-018-0150-6

doi.org/10.1038/s41398-018-0150-6

GWAS on family history of Alzheimer’s disease

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..., Peter M. Visscher

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Translational Psychiatry6.80

Volume: 8, Issue: 1

Published: May 18, 2018

Abstract

Alzheimer’s disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. We show that self-report of parental history of Alzheimer’s dementia for case ascertainment in a genome-wide association study of 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases) is a valid proxy for an AD...

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Paper Details

Title

GWAS on family history of Alzheimer’s disease

DOI

doi.org/10.1038/s41398-018-0150-6

Published Date

May 18, 2018

Journal

Translational Psychiatry

Volume

8

Issue

1

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