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Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans

Published on Jan 30, 2018in Journal of Natural Products 4.26
· DOI :10.1021/acs.jnatprod.7b00525
Fakir Shahidullah Tareq8
Estimated H-index: 8
(University of Bremen),
Fakir Shahidullah Tareq (University of Bremen)+ 7 AuthorsPeter Spiteller19
Estimated H-index: 19
(University of Bremen)
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Abstract
Three new and seven known calopins were isolated from Caloboletus radicans. The structures of the new cyclocalopins, 8-deacetylcyclocalopin B (1), cyclocalopin A-15-ol (2), and 12,15-dimethoxycyclocalopin A (3), were mainly elucidated by NMR and MS data analysis. The stereochemistry of 1–3 was assigned based on NOE correlations and coupling constants and by comparison of their CD spectra with those of similar known calopins. While 1–10 were inactive against two cancer cell lines, they displayed anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus strains (MRSA) with MIC values of 16–256 μg/mL. Moreover, some calopins were active against the fish pathogen Enterococcus faecalis F1B1.
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Published on Feb 1, 2019in Biotechnology Advances 12.83
Birthe Sandargo1
Estimated H-index: 1
,
Clara Chepkirui5
Estimated H-index: 5
+ 4 AuthorsStephan Hüttel7
Estimated H-index: 7
Abstract The Basidiomycota constitutes the second largest higher taxonomic group of the Fungi after the Ascomycota and comprises over 30.000 species. Mycelial cultures of Basidiomycota have already been studied since the 1950s for production of antibiotics and other beneficial secondary metabolites. Despite the fact that unique and selective compounds like pleuromutilin were obtained early on, it took several decades more until they were subjected to a systematic screening for antimicrobial and ...