Abstract LB-B27: Novel antitumor agent GZ17-6.02 exerts discrete effects on transcriptional regulation in pancreatic cancer cells and cancer associated fibroblasts

GZ17-6.02 is a synthetic formulation of Arum palaestinum extracts that has shown significant antitumor activity against a variety of cancer types including pancreatic ductal adenocarcinoma (PDAC). Previous studies have showed that GZ17-6.02 significantly inhibited PDAC tumor growth in an orthotopic xenograft mouse model for PDAC. Mechanistically, GZ17-6.02 suppressed the expression of multiple tumor stem cell markers in PDAC cells. However, the...